ackground & Methods ; It is usual for patients with diabetic neuropathy to have
symptoms of autonomic neuropathy, and we see many studies about the methods for the
usefulness of measurement of fasting salivary glucose secretory rate for assessing the
presence of diabetic autonomic neuropathy, but there are few papers about these in our
country.
The 54 diabetic patients and 60 control subjects were studied and the diabetic patients
were divided into three groups according to the results of tests utilizitn cardiovascular
autonmic nervous reponses (group I: normal control subjects, n=60; group II=diabetic patients
without autonomic neuropathy, n=25; group III; diabetic patients with autonomic neuropathy,
n=29).
Salivary flow rte, salivary glucose concentration and salivary glucose secretory rate were
measure with a glucose oxidase method in each group.
Results;
1) The fasting salivary flow rate in group III was 27.41±1.73 ml/hr, which ws
significantly lower than that of group I 934.85±1.49 ml/hr) and II (33.96±1.80 ml/hr)(p<0.05).
2) The fasting salivary glucose secretory rate in group III was 1.87±0.15 mg/hr,which
was significantly lower than that of group I (2.66±0.23 mg/hr) and II (2.95±0.33 mg/hr)
(p<0.01).
3) There are no significant correlations among the values of postprandial 2 hours salivary
flow rate, salivary glucose concentration, salivary glucose secretory rate of group, I,II and III.
4) None of the fasting and postprandial 2 hours salivary flow rate, salivary glucose
concentrationl, salivary glucose secretory rate are related to the levels of blood glucose and
HbAlc.
Conclustion ; Measurements of fasting salivary glucose secretory rate are helpful for
diagnosis of diabetric autonomic neuropathy.
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